《表2 拉曼光谱不同频带积分能量比》

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《光纤拉曼光谱系统对胃癌的快速诊断的可行性研究》

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Annotation:E1:E1500 cm-1～1600 cm-1；E2:E1600 cm-1～1700 cm-1；E3:E1100 cm-1～1200 cm-1

Overview:Gastric cancer incidence and mortality is high in China.Because of the lack of specificity，the diagnosis accuracy of gastric cancer is not high.Raman spectroscopy is a kind of inelastic scattering spectroscopy based on molecular vibrations，which can provide specific information of structure and composition of tissue.Cancerous tissue can provide characteristic Raman spectra due to its composition content，structural changes.Raman spectroscopy is very suitable for the diagnosis of gastric cancer.Optical fiber Raman spectroscopy system can be used for real-time diagnosis of gastric cancer.The aim of this study was to structure a fiber Raman spectroscopy system matching the gastroscope and combining with the ratios of the spectral integral energy to diagnosis of gastric cancer fast.We used this system to collected 83 spectrum from 29 patients with biopsy examination，including 17 patients with gastric carcinoma and 12 patients with normal gastric mucosa（excitation wavelength of 785 nm light，power of 50 mW，the CCD temperature to80℃，acquisition time 1 s）.Original Raman spectrum contained the weak Raman spectrum of tissue itself we needed，the strong autofluorescence background and noise.By reducing the baseline to remove tissue autofluorescence background and using fast Fourier transform（FFT）to increase signal-to-noise ratio，the original Raman spectrum was preprocessed.And then we got the average spectrum of gastric cancer and normal stomach mucosa tissue respectively and analyzed the ownership of the typical Raman spectrum peak.After standardizing the average spectrum，we calculated the integral energy of Raman spectra.Raman spectrum and the ratio of integral energy from continuous band（1500cm-1～1700 cm-1）and non-continuous band（1100 cm-1～1200 cm-1）were compared.The intensity of Raman peak of gastric adenocarcinoma at 1002 cm-1、1073 cm-1、1450 cm-1、1655 cm-1.Belonging to phenylalanine and proteins are higher than that of normal mucosal relatively.From continuous band（1500 cm-1～1700 cm-1）and non-continuous band（1100 cm-1～1200 cm-1），the ratios of the spectral integral energy of gastric adenocarcinoma were different with normal mucosa markedly（independent samples t test，P<0.05），and with the ratio of the integral energy for use as a diagnostic index，obtained the higher accuracy（97.5%～98.5%），sensitivity（91.7%）and specific degrees（100.0%）.Fiber Raman spectroscopy system applied in the clinical diagnosis of gastric cancer had a high value.