《Table 1–The relative tumor volumes in each group (RTV (%) =V t/V 0×100) .》

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《Evaluation of micelles incorporated into thermosensitive hydrogels for intratumoral delivery and controlled release of docetaxel:A dual approach for in situ treatment of tumors》

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Fig.8 shows the tumor volume as a function of time for four different formulations.The change curves showed that the DTX-MM-hydrogels could achieve a greater tumor inhibition effect compared with the control group.The changes in the tumor volume with the DTX-MM-hydrogels demonstrated the release profiles of the DTX-MM-hydrogels formulation.For example，the tumor volume showed a tiny rise in 2 d，and this may be due to the controlled release of the formulation.Also，the cumulative amount of drug in the DTX-MM-hydrogels was lower compared with the other groups.However，the other two formulations produced a high level of drug accumulation within 2 d and，therefore，they had a better tumor inhibition effect compared with the DTX-MM-hydrogels formulation within 2 d.As is shown in Table 1，the RTV at day 12 after initial therapy was 11.20 for blank hydrogels，6.09 for the DTX-injection，5.42 for DTX-micelles，and 2.38 for DTX-MM-hydrogels.And this shows that the DTX-MM-hydrogels formulation had marked antitumor effects compared with the blank hydrogels group.Also，as shown in Fig.8 B，there was a significant difference in the tumor volume doubling times between the hydrogels group and the other three groups.Compared with blank hydrogels，the tumor volume doubling time in DTX-MM-hydrogels group was significantly increased 2.7-fold.As a result，the DTX-MM-hydrogels reduced the rate of tumor proliferation.Therefore，after administration，a better antitumor efficacy was observed with the DTX-MM-hydrogels formulation over time and this remained stable for a relatively long time.The results obtained in the in vivo antitumor experiments were consistent with the in vitro release behavior.