《The Pharmacological Basis of Therapeutics Second Edition》

SECTION Ⅰ．INTRODUCTION1

1．General Principles1

SECTION Ⅱ．CENTRAL NERVOUS SYSTEM DEPRESSANTS21

2．History and Theories of General Anesthesia21

3．Stages of General Anesthesia28

4．Preanesthetic Medication，Technics of Anesthesia，Anesthetic Accidents，and Properties of Ideal Anesthetics40

5．General Anesthetics Ⅰ．Ether and Chloroform，Vinyl Ether，Ethyl Chloride，and Tri|chloroethylene55

6．General Anesthetics (Continued) Ⅱ．Gas Anesthetics：Nitrous Oxide，Ethylene，and Cyclopropane75

7．Basal Anesthetics93

8．The Aliphatic Alcohols98

9．Hypnotics and Sedatives Ⅰ．The Barbiturates123

10．Hypnotics and Sedatives (Continued) Ⅱ．Bromide，Chloral Hydrate，Paraldehyde，and Miscellaneous Agents (Cannabis，Mescaline)156

11．Drugs Effective in Convulsive Disorders178

12．Centrally Acting Skeletal Muscular Relaxants206

13．Natural and Synthetic Narcotics216

14．Analgesics and Antipyretics Ⅰ．Salicylates and Congeners；Cinchophen and Congeners；Colchicine281

15．Analgesics and Antipyretics (Continued) Ⅱ．Acetanilid and Acetophenetidin；Aminopyrine and Antipyrine311

SECTION Ⅲ．CENTRAL NERVOUS SYSTEM STIMULANTS324

16．Picrotoxin，Pentylenetetrazol，Nikethamide，Strychnine，and Camphor325

17．The Xanthines Caffeine，Theophylline，and Theobromine339

SECTION Ⅳ．LOCAL ANESTHETICS354

18．Cocaine；Procaine and Other Synthetic Local Anesthetics354

SECTION Ⅴ．DRUGS ACTING ON AUTONOMIC EFFECTOR CELLS389

19．Anatomical，Physiological，and General Pharmacological Considerations389

20．Drugs Stimulating Structures Innervated by Cholinergie Nerves (Parasympathomimetic Drugs) Ⅰ．Choline Esters422

21．Drugs Stimulating Structures Innervated by Cholinergic Nerves (Parasympathomimetic Drugs) (Continued) Ⅱ．Cholinesterase Inhibitors and Anti-Curare Agents：Physostigmine，Neostigmine，Diisopropylfluorophosphate，Edrophonium，and Their Congeners444

22．Drugs Stimulating Structures Innervated by Cholinergic Nerves (Parasympathomimetic Drugs) (Continued) Ⅲ．Pilocarpine，Arecoline，and Muscarine470

23．Drugs Stimulating Structures Innervated by Adrenergic Nerves (Sympathomimetic Drugs) Ⅰ．Epinephrine and Levarterenol476

24．Drugs Stimulating Structures Innervated by Adrenergic Nerves (Sympathomimetic Drugs) (Continued) Ⅱ．Ephedrine，Amphetamine，and Other Sympathomimetic Drugs505

25．Autonomic Blocking Agents Ⅰ．Drugs Inhibiting Structures Innervated by Postganglionic Cholinergic Nerves541

26．Autonomic Blocking Agents (Continued) Ⅱ．Drugs Inhibiting Structures Innervated by Adrenergic Nerves：Adrenergic Blocking Agents570

27．Autonomic Blocking Agents (Continued) Ⅲ．Drugs Inhibiting Skeletal Muscles and Autonomic Ganglia596

SECTION Ⅵ．HISTAMINE AND ITS ANTAGONISTS644

28．Histamine and Antihistaminic Agents644

SECTION Ⅶ．CARDIOVASCULAR DRUGS668

29．Digitalis and Allied Cardinc Glycosides668

30．Antiarrhythmic and Antifibrillatory Agents Quinidine and Procaine Amide711

31．Vasodilator and Antihypertensive Agents Nitrites，Thiocyanate，Veratrum Alkaloids，Rauwolfia，Hydralazine，and Khellin730

SECTION Ⅷ．WATER，SALTS，AND INOS764

32．Agents Affecting Volume and Composition of Body Fluids764

33．Cations：Potassium，Calcium，Magnesium，Barium，and Ammonium795

34．Anions：Phosphate，Iodide，Fluoride，and Other Anions835

SECTION Ⅸ．DRUGS AFFECTING RENAL FUNCTION AND ELECTROLYTE METABOLISM840

35．Diuretics and Other Agents Employed in the Mobilization of Edema Fluid840

36．Antidiuretics869

37．Inhibitors of Renal Tubular Transport of Organic Compounds880

SECTION Ⅹ．DRUGS AFFECTING UTERINE MOTILITY886

38．Oxytocics Ergot，Ergot Alkaloids，and Posterior Pituitary886

SECTION Ⅺ．GASES AND VAPORS905

39．The Therapeutic Gases Oxygen，Carbon Dioxide，and Helium905

40．Noxious Gases and Vapors Carbon Monoxide，Hydrocyanic Acid，and Miscellaneous Agents926

SECTION Ⅻ．HEAVY METALS AND HEAVY-METAL ANTAGONISTS939

41．Heavy-Metal Antagonists939

42．Arsenicals948

43．Mercury，Antimony，Gold，and Miscellaneous Metals970

44．Lead1002

SECTION ⅩⅢ．LOCALLY ACTING DRUGS1017

45．Demulcents，Emollients，Protectives，Adsorbents，Hemostatics，Irritants，Astringents，and Certain Enzymes1017

46．Gastric Antacids and Digestants1029

47．Cathartics1049

48．Emetics，Antiemetics，and Expectorants1064

SECTION ⅩⅣ．ANTISEPTICS，DISINFECTANTS，AND DRUGS USED IN THE CHEMOTHERAPY OF INFECTIOUS DISEASES1074

49．Antiseptics，Germicides，Fungicides，Virucides，and Ectoparasiticides1075

50．Drugs Used in the Chemotherapy of Helminthiasis1133

51．Drugs Used in the Chemotherapy of Malaria Quinacrine，Chloroquine，Chloroguanide，Pyrimethamine，Pamaquine，Primaquine，and Quinine1161

52．Drugs Used in the Chemotherapy of Amebiasis Emetine，Halogenated Oxyquinolines，Organic Arsenicals，Chloroquine，and Fumagillin1208

53．Miscellaneous Drugs Used in the Teatment of Protozoal Infections Diamidines and Suramin1228

54．Penicillin Therapy of Syphilis1233

55．Drugs Used in the Chemothernapy of Tuberculosis and Leprosy1250

56．Sulfonamides1276

57．Antibiotics Ⅰ．Penicillin1321

58．Antibiotics (Continued) Ⅱ．Streptomycin and Dihydrostreptomycin1360

59．Antibiotics (Continued) Ⅲ．The Tetracyclines：Chlortetracycline，Oxytetracycline，and Tetracycline1378

60．Antibiotics (Continued) Ⅳ．Miscellaneous Antibiotics：Chloramphenicol，Erythromycin，Carbomycin，Polymyxin B，Neomycin，Bacitracin，and Tyrothricin1394

SECTION ⅩⅤ．DRUGS USED IN THE CHEMOTHERAPY OF NEOPLASTIC DISEASE1414

61．Cytotoxic Drugs，Hormones，and Radioactive Isotopes1415

SECTION ⅩⅥ．DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS1451

62．Drugs Effective in Iron-Deficiency Anemias1451

63．Drugs Effective in Pernicious Anemia and Allied Megaloblastic Anemias Cyanocobalamin (Vitamin B12)，Liver Extract，and Folic Acid1478

64．Anticoagulants Heparin and Bishydroxycoumarin，and Their Congeneric Substitutes1500

SECTION ⅩⅦ．HORMONES AND HORMONE ANTAGONISTS1528

65．Thyroid and Antithyroid Drugs1528

66．Parathyroid1566

67．Anterior Pituitary and Anterior Pituitary-Like Hormones1573

68．Estrogens and progestogens1589

69．Androgens1609

70．Insulin1620

71．Adrenocorticotropic Hormone and Adrenocortical Steroids1642

SECTION ⅩⅧ．THE VITAMINS1692

72．Water-Soluble Vitamins Ⅰ．The Vitamin B Complex1692

73．Water-Soluble Vitamins (Continued) Ⅱ．Ascorbic Acid (Vitamin C)1720

74．Fat-Soluble Vitamins Ⅰ．Vitamin A and Vitamin D1728

75．Fat-Soluble Vitamins (Continued) Ⅱ．Vitamin K and Vitamin E1746

Appendix Ⅰ．Principles of Prescription Writing1759

Appendix Ⅱ．General Principles of Toxicology1777

INDEX1781