《Table 4 Top five up-regulated and top four down-regulated mRNAs in frontotemporal traumatic brain i

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《Expression signatures of long non-coding RNA and mRNA in human traumatic brain injury》

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HSPA1B:Heat shock protein family A（Hsp70）member 1B；HSPA1A:heat shock protein family A（Hsp70）member 1A；PPBP:proplatelet basic protein；IL-8:interleukin 8（also known as C-X-C motif chemokine ligand 8[CXCL8]）；S100A12:S100 calcium binding protein A12；OR7A

GO analysis of the differentially expressed genes was performed to identify the attributes of gene products in cellular components，biological processes，and molecular functions（Shi et al.，2015）.GO analysis showed that the differentially expressed mRNAs were primarily enriched for synaptic transmission，neutrophil chemotaxis，and neuronal action potential propagation（related to biological processes）（Figure 2A） ，plasma membrane，synaptic vesicle，and volt-age-gated potassium channel complex（related to cellular components）（Figure 2B） ，and voltage-gated potassium channel activity，voltage-gated sodium channel activity，and delayed rectifier potassium channel activity（related to molecular functions）（Figure 2C） .Next，we performed pathway analysis using the KEGG database.Dysregulated mRNAswere associated with 27 biological pathways，including legionellosis，influenza A，antigen processing and presentation，rheumatoid arthritis，and the estrogen signaling pathway（Figure 2D）.Altogether，these results suggest that the target genes are linked to 27 signaling pathways，especially those involved in legionellosis and influenza A signaling pathways.The top 10 KEGG pathways related to the target genes are listed in Table 5.