《Table 3:Placebo effect on body weight changes in the antidiabetic treatment between Asian and Cauca

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《亚洲与欧美人群2型糖尿病患者的安慰剂效应比较（英文）》

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In SU treatment group，the use of placebo led to a nonsignificant HbA1c change from baseline（MD，0.187%；95%CI，-0.144–0.518%；P=0.269）in Caucasian population.There was no study in Asian population.In MET treatment group，the placebo effect led to a nonsignificant HbA1c change of 0.127%（95%CI，-0.360–0.613%；P=0.610）in Caucasian population and also a nonsignificant HbA1c change of 0.140%（95%CI，-1.330–1.611%；P=0.852）in Asian population.In AGI treatment group，the placebo effect resulted in an HbA1c change of0.014%without significance（95%CI，-0.275–0.304%；P=0.923）in Caucasians and resulted in a nonsignificant HbA1c change of-0.070%（95%CI，-0.562–0.421%；P=0.779）in Asians.In TZD treatment group，the placebo effect led to a nonsignificant HbA1c change of 0.130%（95%CI，-0.174–0.433%；P=0.402）in Caucasians as well as a nonsignificant HbA1c changeof-0.036%（95%CI，-0.962–0.890%；P=0.939）in Asians.In DPP?4i treatment group，the placebo effect led to a significant decrease in HbA1c（MD，-0.193%；95%CI，-0.311–-0.075%；P=0.001）in Caucasian population and also a significant reduction of HbA1c（MD，-0.162%；95%CI，-0.289–-0.035%；P=0.012）in Asian population.In SGLT2i treatment group，the placebo effect resulted in a significant decrease in HbA1c（MD，-0.230%；95%CI，-0.340–-0.121%；P<0.001）in Caucasians while it resulted in a nonsignificant HbA1c change of-0.047%（95%CI，-0.543–0.449%；P=0.853）in Asian population.In GLP?1RA treatment group，the placebo effect led to an HbA1c change of-0.172%（95%CI，-0.383–0.038%；P=0.109）without significance in Caucasians and also a nonsignificant HbA1c change of-0.214%（95%CI，-0.448–0.021%；P=0.074）in Asians[Table 2].Comparisons of the placebo effect in HbA1c changes relative to baseline indicated that no significant difference was found between Asian and Caucasian population in MET，AGI，TZD，DPP?4i，SGLT?2i，and GLP?1RA treatment.Since no studies of Asian population in SU treatment，it was concerned lack of evidence for comparing the Asian and Caucasian population in this category[Table 2 and Supplementary Figures S3?S15].