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CHAPTER 1.GROWTH AND DEVELOPMENT1

Normal Growth and Development1

Disturbances of Physical Growth4

Mongolism9

CHAPTER 2.THE NEWBORN12

General Classification12

Postmortem Examination14

Anatomic Changes Peculiar to Newborn Period16

Infections in Newborn Period21

Antenatal Infections21

Specific Lesions of Other Organs27

Lesions of Unknown Etiology or Significance28

CHAPTER 3.PREMATURITY AND POSTMATURITY34

Definitions34

Prematurity35

Postmaturity43

The Giant Fetus45

CHAPTER 4.DISEASES OF THE PLACENTA48

Abnormalities of Attachment,Separation and Position48

Abnormalities of Form49

Tumors49

Specific Lesions50

CHAPTER 5.ERYTHROBLASTOSIS FETALIS52

Etiology of Erythroblastosis Fetalis52

Pathogenesis of Erythroblastosis Fetalis54

Kernicterus56

CHAPTER 6.CONGENITAL MALFORMATIONS60

General Data60

Experimental Teratology64

CHAPTER 7.INBORN ERRORS OF METABOLISM71

Terminology71

Errors in Protein Metabolism71

Errors in Carbohydrate Metabolism73

Errors in Lipid Metabolism76

Errors in Pigment Metabolism82

Metabolic Diseases of Unknown Mechanisms83

CHAPTER 8.NUTRITIONAL DISEASES91

General Data91

Malnutrition and Starvation91

Obesity91

Vitamin Deficiencies92

Deficiencies of Other Substances108

Multiple and Combined Nutritional Deficiencies or Both110

CHAPTER 9.DISEASES RELATED TO HYPERSENSITIVITY114

General Data114

Description of Specific Diseases114

CHAPTER 10.DISEASES CAUSED BY POISONS123

General Data123

Corrosives123

Gaseous Poisons124

Metallic Poisons125

Organic Compounds128

CHAPTER 11.SUDDEN AND UNEXPECTED DEATH IN INFANCY133

Description and Possible Causes133

CHAPTER 12.TUMORS136

An Hypothesis on the Nature of Tumors136

Tumors of Childhood139

CHAPTER 13.DISEASES CAUSED BY BACTERIA147

General Data147

General Bacterial Diseases148

Specific Bacterial Diseases154

Tuberculosis169

Leprosy180

CHAPTER 14.DISEASES CAUSED BY SPIROCHETES185

General Description185

Specific Diseases185

CHAPTER 15.DISEASES CAUSED BY RICKETTSIA AND OTHER ORGANISMS204

Diseases caused by Rickettsia204

Miscellaneous Infections207

CHAPTER 16.DISEASES CAUSED BY VIRUSES210

Introduction210

General Characteristics of Lesions Caused by Viruses210

Immunity to Viral Diseases211

Specific Viral Diseases213

CHAPTER 17.DISEASES CAUSED BY FUNGI247

Concept of Pathogenicity247

General Pathologic Anatomy of Mycotic Lesions248

Specific Fungus Diseases250

CHAPTER 18.DISEASES CAUSED BY PROTOZOA259

General Description259

Specific Diseases259

CHAPTER 19.DISEASES CAUSED BY WORMS AND ARTHROPODS276

General Data276

Nematode Infestations276

Platyhelminth Infestations283

Tick Paralysis291

CHAPTER 20.DISEASES OF THE CENTRAL NERVOUS SYSTEM292

General Data292

Development of Central Nervous System296

Congenital Malformations of Brain297

Congenital Malformations of Spinal Cord303

Other Congenital Anomalies and Diseases304

Infantile Cerebral Palsy308

Hydrocephalus309

Cerebral Injury at Birth312

Hereditary Degenerative Diseases312

Nonhereditary Degenerative Diseases of Spinal Cord326

Vascular Lesions of Central Nervous System328

Inflammations of Nervous System329

Neoplasms of Central Nervous System333

CHAPTER 21.TUMORS OF THE PERIPHERAL NERVOUS SYSTEM347

Malignant and Benign Tumors347

CHAPTER 22.DISEASES OF THE SPECIFIC SENSORY ORGANS353

Diseases of Eye and Adnexa353

Diseases of Ear358

Diseases of Nose359

Diseases of Lips361

Diseases of Mouth and Tongue362

Diseases of Teeth364

Diseases of Jaws369

Diseases of Salivary Glands369

Diseases of Pharynx370

CHAPTER 23.DISEASES OF THE RESPIRATORY SYSTEM374

General Data374

Congenital Anomalies of Lung374

Congenital Anomalies of Trachea and Larynx379

Pulmonary Lesions Associated with Circulatory Disorders380

Lesions of Pulmonary Vessels381

Lesions Associated With Interference of Pulmonary Ventilation382

Infectious Diseases of Respiratory System384

Miscellaneous Diseases of Lung391

Tumors of Respiratory System393

Diseases of Pleura and Thoracic Cavity395

Diseases of Mediastinum395

Diseases of Diaphragm and Chest Wall396

CHAPTER 24.DISEASES OF THE HEART AND BLOOD VESSELS399

General Data399

Congenital Heart Diseases399

Infectious Diseases of Heart413

Diseases of Coronary Arteries414

Rheumatic Fever415

Nonspecific Degenerative Lesions of Heart422

Peculiarities of Fetal and Newborn Heart422

Tumors of Heart423

Diseases of Blood Vessels424

Tumors of the Blood Vessels425

CHAPTER 25.DISEASES OF THE BLOOD430

General Data430

Generic Classification of Diseases of Blood431

Congenital Anomalies of Blood432

Infectious Diseases of Blood438

Effect of Nutritional Deficiencies on Blood439

Disorders of Blood Associated with Toxic or Unknown Agents440

Diseases of Blood Related to Hypersensitivity443

Neoplastic Diseases of Blood444

CHAPTER 26.DISEASES OF THE SPLEEN AND LYMPH NODES449

General Data449

Diseases of Spleen449

Diseases of Lymph Nodes451

CHAPTER 27.DISEASES OF THE GASTROINTESTINAL TRACT460

General Data460

Embryologic Development460

Diseases of Esophagus462

Diseases of Stomach465

Diseases of Small Intestines467

Diseases of Colon473

Diseases of Peritoneum,Mesentery,and Abdominal Walls477

Malformations of Anus and Rectum480

Appendicitis480

CHAPTER 28.DISEASES OF THE LIVER484

General Comparative Data484

Embryology484

Jaundice486

Congenital Anomalies of Liver487

Degenerations of Liver488

Necrosis of Liver489

Infections of Liver490

Miscellaneous Diseases of Liver496

Infantile and Juvenile Cirrhosis496

Tumors of Liver497

CHAPTER 29.DISEASES OF THE EXTRAHEPATIC BILIARY SYSTEM502

Structure of Gallbladder and Biliary Ducts502

Congenital Malformations of Biliary System502

Acquired Diseases of Biliary System508

Tumors of Biliary System508

CHAPTER 30.DISEASES OF THE PANCREAS510

Congenital Anomalies of Pancreas510

Acquired Diseases of Pancreas510

Pancreatic Lesions in Chronic Renal Disease511

Cysts of Pancreas512

Tumors of Pancreas512

CHAPTER 31.DISEASES OF THE GENITOURINARY SYSTEM513

Statistical Significance513

Embryology513

Postnatal Histologic Development517

Congenital Anomalies of Genitourinary System517

Acquired Diseases of Kidney526

Diseases of Lower Genitourinary Tract537

Precocious Puberty546

CHAPTER 32.DISEASES OF THE ENDOCRINE GLANDS549

General Data549

The Pituitary Gland549

The Pineal Gland554

The Thyroid Gland555

The Parathyroids563

The Adrenal Glands565

The Paraganglia571

The Thymus572

CHAPTER 33.DISEASES OF THE BONES AND JOINTS578

Mode of Classification578

Congenital Absence of Bones or Parts of Bones578

Hypoplasia of Bones579

Hyperplasia of Bones579

Alterations in Chondromatous Element of Bone581

Deficient Osteoblastic Formation of Bone585

Destructive Lesions of Bone586

Neoplastic Lesions of Bone592

Other Tumors of Bone600

Diseases of Joints601

CHAPTER 34.DISEASES OF THE MUSCLES AND SUPPORTING TISSUES607

General and Technical Data607

Congenital Abnormalities607

Muscular Dystrophies608

Neural Lesions610

Diseases of Nervous System with Outstanding Effects on the Muscular Apparatus611

Diseases of Muscle of Unknown Etiology612

Effects of Generalized Disease on Striated Muscle613

Tumors of Muscle614

Tumors of Fibrous Tissue and Tendon614

Diseases of Tendon618

CHAPTER 35.DISEASES OF THE SKIN620

General Description620

Embryology of Skin620

Congenital Anomalies of Skin621

Infectious Inflammatory Diseases627

Noninfectious Inflammatory Diseases629

Tumors of Skin637

Tumors of Adnexal Structures642

APPENDIX649

INDEX661

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