《Table 2Effects of HA1 on transplant tumor (MCF-7) weight in nude mice (ˉx±s) .》

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《Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/m TOR signaling pathway》

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*P<0.05**P<0.01 vs model group

On day 11，H22 xenograft tumor was excised from each sacrificed animal and weighed.Compared with the vehicle control，HA1 markedly decreased the weight of tumor in mice.The growth of H22 tumors was inhibited at 31.9%and 44.1%（P<0.01）compared with vehicle-treated animals by administering HA1 at the dose of 4.5 and 6.0 mg/kg，respectively.Inhibited tumor growth of HA1 in vivo was further assessed in BALB/c mice transplanted with human breast cancer MCF-7 tumor.Oral intake of HA1（3.75，7.5，and 15.0 mg/kg）significantly inhibited the weight of tumor in BALB/c mice，in comparison with the vehicle control.The growth of MCF-7 tumors was inhibited at 33.11%and 52.38%（P<0.01compared with vehicle-treated animals）by administering HA1 at the dose of 7.5 and 15.0 mg/kg，respectively.Similar antitumor growth effects were detected in mice treated with CTX in the positive control group.Tumor weight was described in Tables 1 and2.