《RADIOISOTOPE STUDIES OF FATTY ACID METABOLISM》

1．DIGESTION AND ABSORPTION1

Early experiments1

Site of absorption2

Digestion3

Action of pancreatic lipase5

Participation of phospholipids7

Origin and fate of glycerol9

Determination of state of absorption10

Absorption of fatty acids as phospholipids11

Absorption of fatty acids as sterol esters12

2．TRANSPORT,DEPOSITION AND MOBILIZATION OF FATTY ACIDS15

Blood transport15

Deposition18

Mobilization21

3．TURNOVER AND METABOLIC INFLUENCES23

Turnover studies23

Turnover experiments with acetate26

Turnover experiments with fatty acids29

Relationships of carbohydrate and fatty acid metabolism31

Hormonal influences34

Fatty acid metabolism in tumors34

4．BETA OXIDATION OF FATTY ACIDS37

Acetoacetate formation37

Conversion to carbohydrate42

Fatty acid oxidation in plants43

5．INTERCONVERSIONS OF FATTY ACIDS46

The saturated and monounsaturated acids46

The polyunsaturated acids51

6．BIOSYNTHESIS57

Fatty acid synthesis in animals57

Fatty acid synthesis in plants68

7．PHOSPHOLIPIDS72

Biosynthesis74

Catabolism80

Function82

8．STEROL ESTERS88

Sterol esterification during absorption90

Blood sterol and sterol esters95

Liver sterol esters98

Fatty acid spectra of sterol esters99

9．PROSPECTUS104

Appendix Ⅰ．Preparation of labeled fatty acids108

Biosynthesis108

Laboratory synthesis110

Appendix Ⅱ．Controlled degradation of labeled fatty acids119

AUTHOR INDEX131

SUBJECT INDEX137