《Table 1 Summary of experimental parameters and results of Ifnar–/–mice challenged with various outb
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《Type Ⅰ interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential》
IM:Intramuscular;IN:Intranasal;SC:Subcutaneous;IP:Intraperitoneal;ID:Intradermal;IV:Intravenous.
Immunocompromised Ifnar–/–mice have been shown to be a very good alternative small animal model for highly virulent pathogens that do not cause disease in immunocompetent mice.In this review,we described the different parameters and results from experimental infection of Ifnar–/–mice with various pathogens(Table 1).It is obvious that the advent of Ifnar1–/–mice undoubtedly constituted a major step forwards in allowing researchers to easily and rapidly study the pathogenesis of clinical isolates during a potential outbreak situation,as these animals are more susceptible to viral infections(Table 2).
图表编号 | XD0016284100 严禁用于非法目的 |
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绘制时间 | 2018.01.18 |
作者 | Gary Wong、Xiang-Guo Qiu |
绘制单位 | Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital、Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences、Special Pathog |
更多格式 | 高清、无水印(增值服务) |
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