《Table 1 Serum cardiac markers of the patient during acute coronary syndrome onset》

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《Tegafur deteriorates established cardiovascular atherosclerosis in colon cancer: A case report and review of the literature》

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cTnI:Cardiac troponin I；cTnT:Cardiac troponin T；CK-MB:Creatine kinase-MB；Mb:Myoglobin；PRO-BNP:Pro-brain natriuretic peptide；PCT:Procalcitonin.

The patient periodically went back to our hospital for review.He had no documented complaints of discomfort and showed no obvious adverse reaction until the fifth cycle of single S-1 chemotherapy on October 28，2017.He developed retrosternal pain.ECG showed extensive ST-T segment depression along with inversed T wave（Figure 4）.A serial of cardiac markers were continuously detected during the onset（Table 1），among which serum cTnT and pro-brain natriuretic peptide levels were extremely elevated.In retrospect of CT scan of the heart and after consultation with cardiologists，the patient was diagnosed with NSTE-ACS.Considering D-dimer was elevated after the outbreak of ACS（1.66 mg/L；normal range:<0.55 mg/L），antiplatelet and anticoagulant protocols were applied to stabilize plaque.Improvement of myocardial metabolism and nutritional support were also applied.