《Table 4–Pharmacokinetics properties and bioavailability of various UA nanosystems.》

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《Evolution from small molecule to nano-drug delivery systems:An emerging approach for cancer therapy of ursolic acid》

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With significant advances achieved in nanotechnologies，constructing drug-loaded nanosystems is considered to be one of the most promising strategies for cancer therapy.The advantages and disadvantages of different UA nanosystems are sequentially discussed in Table 5.Despite numerous progress has been made in recent years，there are still some challenges in the clinical applications of UA nanosystems.（i）Some nanocarriers of UA possibly aggregate or agglomerate with other biomolecules or biological fluids in vivo[123].（ii）The stability and storage aspects of UA nanosystems are still needed to be further improved.（iii） Complex preparation methods of UA nanosystems will lead to some problems such as potentially toxic to healthy tissues，indistinct metabolism，as well as biodegradation problems.（iv） Many physiological barriers will certainly limit the deep penetration of UA nanosystems into the tumor tissues and subsequently impact the therapeutic outcome.These challenges must be addressed in order to promote UA nanosystems to become the nextgeneration nanomedicine.