《Table 1Artificial metalloenzymes with promising catalytic functionalities.》

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《生物催化进展:从计算到代谢工程（英文）》

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Hydrogenation reactions have been reported utilizing an ar‐tificial metalloenzyme（ArM）for avidin protein[51].Recently，artificial metalloenzymes were applied for several purposes，suchasincell‐freeextracts[52，53]，whole‐cell bio‐transformations[52，54，55]，and in vivo applications[10，56].Through these approaches，the field of artificial metal‐loenzymes，biorthogonal chemistry，and synthetic biology are used，which enhances catalytic capabilities for producing tar‐geted molecules[57，58].From the industrial perspective，en‐zyme engineering offers an eco‐friendly solution for generating desired catalytic activity[59].Metals attached to enzymes alter enzyme characteristics；because of their stability，de novo con‐struction of ArMs remain limited[60].However，a de novo bio‐logical catalyst can establish bonds between carbon and silicon[52，61]，as well as carbon and boron bonds[62，63].Therefore，natural enzymes have been modified by introducing non‐inherited catalytic activities[56，64].In another study，an in silico approach in combination with an evolutionary approach were used to produce organophosphate hydrolase[64].Some other artificial metalloenzymes with promising catalytic func‐tionalities are summarized in Table 1.