《Table 2.IC50 values of compounds 1, 2, 4, 6–7, 10, 12–15 and 19 against the corresponding tumor cel

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《氧杂蒽酮的合成和抗肿瘤、抑制酪氨酸酶和抑制血小板聚集活性研究（英文）》

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The in vitro cytotoxic activity of compounds 1–10and 19 was assessed in four cancer cell lines，including human hepatoma cell line SK-HEP-1，human lung cancer cell line SPC-A-1，human paclitaxel-resistant lung cancer cell line A549/Taxol and mouse breast cancer cell line（4T1），using the 3-（4，5-dimethylthiazol-2-yl）-5-（3-carboxymethoxyphenyl）-2-（4-sulfophenyl）-2H-tetrazolium，inner salt（MTS）assay[15].Meanwhile，compounds 11–18were evaluated for their in vitro cytotoxic activity against hepatocarcinoma cell line SMMC-7721 in the same way.Two anticancer drugs，cisplatin and Taxol，were co-assayed as the positive controls.The results are listed in Table 1.The inhibition rates of the compounds were greater than 50%，and the IC50 values（concentration required to inhibit tumor cell proliferation by 50%）relative to the corresponding tumor cell lines were determined subsequently.These results are listed in Table 2.