《Table 1 Characteristics of animal models for HBV study》

《Table 1 Characteristics of animal models for HBV study》   提示：宽带有限、当前游客访问压缩模式
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《Animal models for the study of hepatitis B virus infection》


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The first human liver chimeric mouse model was developed in immunodeficient（Rag2-/-，SCID，SCID/beige）mice with the urokinase-type plasminogen activator（u PA）transgene.The expression of the u PA gene can induce necrosis of hepatocytes，leading to subacute liver failure in young mice，and making it possible to transplant human hepatocytes into mouse livers.Transplantation of human hepatocytes into u PA-SCID mice results in a liver-humanized model with high human hepatocyte reconstitution rate and supportive of HBV and HCV infection（Dandri et al.，2001；Tsuge et al.，2005）（Table 1） .

图表编号XD0016284500    严禁用于非法目的
绘制时间2018.01.18
作者Wei-Na Guo、Bin Zhu、Ling Ai、Dong-Liang Yang、Bao-Ju Wang
绘制单位Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology、Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology、Department of
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