《an introduction to genetic analysis sixth edition P916》求取 ⇩
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1 GENETICS AND THE ORGANISM1
Genetics and Human Affairs3
Genetics and Biology7
Genes and Environment11
Techniques of Genetic Analysis17
2MENDELIAN ANALYSIS21
Mendel’s Experiments22
Simple Mendelian Genetics in Humans32
Simple Mendelian Genetics in Agriculture37
Variants and Genetic Dissection40
3CHROMOSOME THEORY OF INHERITANCE55
Mitosis and Meiosis56
The Chromosome Theory of Heredity62
Sex Chromosomes and Sex Linkage70
The Parallel Behavior of Autosomal Genes and Chromosomes76
Mendelian Genetics and Life Cycles76
4EXTENSIONS OF MENDELIAN ANALYSIS91
Variations on Dominance92
Multiple Alleles93
Lethal Alleles95
Several Genes Affecting the Same Character98
Penetrance and Expressivity108
5LINKAGE Ⅰ:BASIC EUKARYOTIC CHROMOSOME MAPPING123
The Discovery of Linkage124
Recombination126
Linkage Symbolism127
Linkage of Genes on the X Chromosome128
Linkage Maps129
Three-Point Testcross131
Interference134
Calculating Recombinant Frequencies from Selfed Dihybrids135
Examples of Linkage Maps135
The X2 Test137
The Nature of Crossing-Over140
Linkage Mapping by Recombination in Humans142
6LINKAGE Ⅱ:SPECIAL EUKARYOTIC CHROMOSOME MAPPING TECHNIQUES155
Accurate Calculation of Large Map Distances156
Analysis of Single Meioses159
Mitotic Segregation and Recombination167
7GENE MUTATION181
Somatic versus Germinal Mutation182
Mutant Types184
The Occurrence of Mutations187
Selective Systems191
Mutation Induction197
Mutation and Cancer199
Mutagens in Genetic Dissection201
Mutation Breeding203
8CHROMOSOME MUTATION Ⅰ:CHANGES IN CHROMOSOME STRUCTURE211
The Topography of Chromosomes213
Types of Changes in Chromosome Structure216
Chromosomal Rearrangements in Evolution234
9CHROMOSOME MUTATION Ⅱ:CHANGES IN NUMBER249
Aberrant Euploidy250
Aneuploidy258
Chromosome Mechanics in Plant Breeding266
10RECOMBINATION IN BACTERIA AND THEIR VIRUSES275
Working with Microorganisms276
Bacterial Conjugation277
Bacterial Recombination and Mapping the E.coli Chromosome286
Bacterial Transformation290
Bacteriophage Genetics291
Transduction298
Chromosome Mapping302
Bacterial Gene Transfer in Review302
11THE STRUCTURE OF DNA313
DNA:The Genetic Material314
The Structure of DNA315
Replication of DNA321
Mechanism of DNA Replication326
DNA Replication in Eukaryotes332
DNA and the Gene334
12THE NATURE OF THE GENE341
How Genes Work342
Gene-Protein Relationships345
Genetic Fine Structure358
Mutational Sites364
Complementation369
13DNA FUNCTION383
Transcription384
Translation389
The Genetic Code392
Protein Synthesis399
Universality of Genetic Information Transfer406
Eukaryotic RNA408
Mechanism of Gene Splicing412
Review416
14RECOMBINANT DNA TECHNOLOGY423
Making Recombinant DNA424
Cloning a Specific Gene430
Fractionation of DNA by Electrophoresis442
DNA Sequence Determination444
The Polymerase Chain Reaction448
Restriction Maps449
15APPLICATIONS OF RECOMBINANT DNA TECHNOLOGY459
In Vitro Mutagenesis460
Gene Synthesis462
Expressing Eukaryotic Genes in Bacteria463
Reverse Genetics464
Recombinant DNA Technology in Eukaryotes465
Gene Therapy478
Recombinant DNA and Screening for Genetic Diseases482
16THE STRUCTURE AND FUNCTION OF EUKARYOTIC CHROMOSOMES493
Genome Size in Eukaryotes494
One DNA Molecule per Chromosome494
The Role of Histone Proteins in Packaging DNA497
Higher-Order Coiling497
Heterochromatin and Euchromatin500
Chromosome Bands501
Centromeric DNA502
Sequence Organization504
Replication and Transcription of Chromatin513
17GENOMICS519
Assigning Loci to Specific Chromosomes520
Chromosome Mapping524
Physical Mapping of Genomes530
Genetic Analysis Using Physical Maps533
Genome Sequencing536
18CONTROL OF GENE EXPRESSION545
Basic Control Circuits546
Discovery of the lac System:Negative Control547
Catabolite Repression of the lac Operon:Positive Control554
Dual Positive and Negative Control:The Arabinose Operon555
Metabolic Pathways558
The Tryptophan Genes:Negative Control with Superimposed Attenuation559
The λ Phage:A Complex of Operons562
Multioperon Repression564
Structure of Regulatory Proteins564
Transcription:Gene Regulation in Eukaryotes—An Overview564
Cis Control of Transcription566
Trans Control of Transcription568
Regulation of Transcription Factors573
5-Methylcytosine Regulation575
Post-Transcriptional Control575
Control of Ubiquitous Molecules in Eukaryotic Cells576
19MECHANISMS OF GENETIC CHANGE Ⅰ:GENE MUTATION583
The Molecular Basis of Gene Mutations585
Spontaneous Mutations586
Induced Mutations593
Reversion Analysis600
The Relationship between Mutagens and Carcinogens600
Repair Defects and Human Diseases612
20MECHANISMS OF GENETIC CHANGE Ⅱ:RECOMBINATION617
General Homologous Recombination618
The Holliday Model619
Enzymatic Mechanism of Recombination626
Site-Specific Recombination630
Recombination and Chromosomal Rearrangements631
Duplication and Evolution631
21MECHANISMS OF GENETIC CHANGE Ⅲ:TRANSPOSABLE GENETIC ELEMENTS637
Insertion Sequences638
Transposons640
Phage Mu644
Mechanism of Transposition644
Rearrangements Mediated by Transposable Elements646
Review of Transposable Elements in Prokaryotes648
Ty Elements in Yeast650
Transposable Elements in Drosophila650
Retroviruses653
Transposition via an RNA Intermediate655
Controlling Elements in Maize656
Review of Transposable Elements inEukaryotes660
22THE EXTRANUCLEAR GENOME663
Extranuclear Inheritance in Higher Plants665
Extranuclear Inheritance in Fungi666
Shell Coiling in Snails:A Red Herring668
Extranuclear Genes in Chlamydomonas668
Mitochondrial Genes in Yeast672
An Overview of the Mitochondrial Genome676
An Overview of the Chloroplast Genome678
Mitochondrial Diseases in Humans680
Extragenomic Plasmids in Eukaryotes680
How Many Copies?683
23GENE REGULATION DURING DEVELOPMENT693
Regulating the Synthesis of Proteins694
Tissue-Specific Regulation at the Level of DNA Structure694
Regulation of Gene Transcription695
Transcript Processing and Tissue-Specific Regulation696
Post-transcriptional Regulation697
Post-translational Regulation698
Epigenetic Inheritance698
Dissecting Eukaryotic Regulatory Elements700
Regulatory Elements and Dominant Mutations703
Regulatory Cascades:Applying Regulatory Mechanisms to Developmental Decisions704
The Sex Determination Pathway in Drosophila705
Sex Determination in Mammals709
The Pathway of Antibody Production:DNA Gene Rearrangement and Antibody Diversity712
24GENETICS AND CELLULAR DIFFERENTIATION719
The Cytoskeleton and Cellular Architecture720
The Cell Cycle725
Intercellular Communication729
Cancer:A Genetic Disease of Somatic Cells736
25DEVELOPMENTAL GENETICS:CELL FATE AND PATTERN FORMATION747
Pattern Formation:The Establishment of the Basic Animal Body Plan748
A Sneak Preview of Pattern Formation748
Investigating Early Development750
A Synopsis of Early Drosophila Development751
Establishing Positional Information754
The A/P Morphogens755
The D/V Morphogen758
The Establishment of Polarity in the Oocyte760
The Initial Response to Positional Information761
Refining the Initial Patterning Decisions762
A Cascade of Regulatory Events764
Determination of Segment Identity766
Homeotic Mutations and the Establishment of Segmental Identity766
Applying the Fly Lesson to Other Organisms:Mouse Molecular Genetics769
26POPULATION GENETICS779
Darwin’s Revolution780
Variation and Its Modulation780
The Effect of Sexual Reproduction on Variation789
The Sources of Variation791
Selection797
Balanced Polymorphism802
Multiple Adaptive Peaks804
Artificial Selection805
Random Events807
A Synthesis of Forces808
The Origin of Species811
27QUANTITATIVE GENETICS817
Some Basic Statistical Notions819
Genotypes and Phenotypic Distribution826
Norm of Reaction and Phenotypic Distribution828
The Heritability of a Trait830
Quantifying Heritability831
Determining Norms of Reaction835
Locating the Genes838
Gene Action840
More on Analyzing Variance842
FURTHER READING851
GLOSSARY859
ANSWERS TO SELECTED PROBLEMS880
INDEX901
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